Afanix 40 mg (Afatinib)

What is Afanix 40mg?

Afanix 40mg is known to be one of the products used effectively for the treatment of non-small cell lung cancer. Afanix medicine 40mg with the active ingredient Afatinib acts on the target cancer cells, preventing its growth, along with making them self-destruct.

Basic information of Afanix 40mg

• Active ingredient: Afatinib.
• Categories: Anticancer drugs, protein kinase inhibitors.
• Trade name: Afanix.
• Preparation: Film-coated tablets.
• Packaging: Box of 3 blisters x 10 tablets.
• Origin: Beacon- Bangladesh.

Ingredients 

• Each Afanix 40mg tablet contains:
• Afatinib as afatinib dimaleate - 40mg.
• Excipients 1 capsule.

Pharmacological properties 

• Afatinib is a powerful and selective, irreversible ErbB Family Blocker.
• Afatinib binds covalently and irreversibly blocks signals from all homozygotes and heterozygotes formed by ErbB family members EGFR (ErbB1), HER2 (ErbB2), ErbB3 and ErbB4.

Pharmacokinetics:

• Absorption: Following oral administration of Afanix, the bioavailability of afatinib is observed approximately 2 to 5 hours after dosing.
• Distribution: The binding of afatinib to human plasma proteins is approximately 95%.
• Metabolism: Enzyme-catalyzed metabolic reactions play a negligible role for afatinib in vitro. Protein covalent products are the major cyclic metabolites of afatinib.
• Elimination: Following administration of 15 mg afatinib oral solution, 85.4% of the administered dose was recovered in feces and 4.3% in urine. The parent compound afatinib accounted for 88% of the recovered dose. Afatinib is eliminated with an effective half-life of approximately 37 hours.

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