Afanix 40 mg (Afatinib)

Afatinib is basically Anti-Cancer Medicine and it is used for the first-line treatment of patients with metastatic non-small cell lung cancer.

Product Name : Afanix (Afatinib)
Generic Name : Afatinib Dimaleate INN
Formulation : Tablet
Available Pack Size : 30’s (3×10’s)
Available Strengths : 40 mg
Registrations : Bangladesh
Category:

Product Description

What is Afanix 40mg?

Afanix 40mg is known to be one of the products used effectively for the treatment of non-small cell lung cancer. Afanix medicine 40mg with the active ingredient Afatinib acts on the target cancer cells, preventing its growth, along with making them self-destruct.

Basic information of Afanix 40mg

  • Active ingredient: Afatinib.
  • Categories: Anticancer drugs, protein kinase inhibitors.
  • Trade name: Afanix.
  • Preparation: Film-coated tablets.
  • Packaging: Box of 3 blisters x 10 tablets.
  • Origin: Beacon- Bangladesh.

Ingredients 

  • Each Afanix 40mg tablet contains:
  • Afatinib as afatinib dimaleate - 40mg.
  • Excipients 1 capsule.

Pharmacological properties 

  • Afatinib is a powerful and selective, irreversible ErbB Family Blocker.
  • Afatinib binds covalently and irreversibly blocks signals from all homozygotes and heterozygotes formed by ErbB family members EGFR (ErbB1), HER2 (ErbB2), ErbB3 and ErbB4.

Pharmacokinetics:

  • Absorption: Following oral administration of Afanix, the bioavailability of afatinib is observed approximately 2 to 5 hours after dosing.
  • Distribution: The binding of afatinib to human plasma proteins is approximately 95%.
  • Metabolism: Enzyme-catalyzed metabolic reactions play a negligible role for afatinib in vitro. Protein covalent products are the major cyclic metabolites of afatinib.
  • Elimination: Following administration of 15 mg afatinib oral solution, 85.4% of the administered dose was recovered in feces and 4.3% in urine. The parent compound afatinib accounted for 88% of the recovered dose. Afatinib is eliminated with an effective half-life of approximately 37 hours.

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